When these two hormones are combined, it represents anabolic and catabolic balance. Since DHEA acts not only as an anabolic hormone but appears to down-regulate the cellular effects of cortisol, this measurement can theoretically enhance the predictive value of HPA axis dysfunction.
Several factors can contribute to an imbalanced ratio:
An imbalanced DHEA
ratio can manifest through various symptoms:
Dehydroepiandrosterone (DHEA) and cortisol are produced in the adrenal glands, and are both derived from pregnenolone.. These two markers have opposite functions when released by the body.
Cortisol and DHEA-S have opposing actions on immune function. DHEA-S levels are dramatically decreased in chronic inflammatory diseases whereas cortisol levels remain stable or are elevated.
DHEA and cortisol are the most abundant hormones released by the adrenal glands, and both play a role in the stress response.
Together, cortisol and DHEA enable the physiological changes associated with stress, and both mediate short- and long-term responses to stress.
When these two hormones are combined, it represents anabolic and catabolic balance. Since DHEA acts not only as an anabolic hormone but appears to down-regulate the cellular effects of cortisol, this measurement can theoretically enhance the predictive value of HPA axis dysfunction.
Several factors can contribute to an imbalanced ratio:
An imbalanced DHEA
ratio can manifest through various symptoms:
Dehydroepiandrosterone (DHEA) and cortisol are produced in the adrenal glands, and are both derived from pregnenolone.. These two markers have opposite functions when released by the body.
Cortisol and DHEA-S have opposing actions on immune function. DHEA-S levels are dramatically decreased in chronic inflammatory diseases whereas cortisol levels remain stable or are elevated.
DHEA and cortisol are the most abundant hormones released by the adrenal glands, and both play a role in the stress response.
Together, cortisol and DHEA enable the physiological changes associated with stress, and both mediate short- and long-term responses to stress.